It would be tough but depending on the pitcher and control I would.
Having a true ace is critical for yearly world series contention. Id have no problem with Collins and Abreu splitting time at DH, Eloy moving to 1st, and us finding a competent left fielder, IF we could bring in a bona-fide ace. Losing Vaughn would hurt, but it is about maximizing the roster to win titles.
I know we have Kopech, Gio, and Cease, but if we move those guys down and have DK as a five with Rodon and Lopez in the bullpen, that becomes a multiple championship caliber staff to go with a championship caliber offense.