StrangeSox Posted January 25, 2021 Share Posted January 25, 2021 (edited) 5 minutes ago, Texsox said: We should have done this like we did polio, through churches and schools. Shut school buildings down and use the school nurses. Schools are using school nurses to deliver shots to staff. But the states are just dumping a handful of doses on districts and telling them "hey, figure it out yourself." It all started with the complete and utter failure of the federal government, but just about every state is compeltely failing and abdicating responsibility as well. Why the hell is it up to school superintendents, who have zero public health background, to determine if/when their schools should be open and the vaccine priority and distribution for their schools? Why is Linconl-Way having to develop vaccination plans and submit them to the local health departments? https://patch.com/illinois/newlenox/lincoln-way-districts-submit-vaccination-plans-health-dept Anyway, wonder what you'd see if you overlaying these maps with demographic and poverty heat maps ? Edited January 25, 2021 by StrangeSox Link to comment Share on other sites More sharing options...
bmags Posted January 25, 2021 Share Posted January 25, 2021 1 minute ago, StrangeSox said: Schools are using school nurses to deliver shots to staff. But the states are just dumping a handful of doses on districts and telling them "hey, figure it out yourself." It all started with the complete and utter failure of the federal government, but just about every state is compeltely failing and abdicating responsibility as well. Why the hell is it up to school superintendents, who have zero public health background, to determine if/when their schools should be open and the vaccine priority and distribution for their schools? Anyway, wonder what you'd see if you overlaying these maps with demographic and poverty heat maps ? Nice map of where doctors live. Link to comment Share on other sites More sharing options...
StrangeSox Posted January 25, 2021 Share Posted January 25, 2021 Just now, bmags said: Nice map of where doctors live. What about nurses, CNA's, reception, security, and other frontline people exposed to COVID patients in medical settings? Link to comment Share on other sites More sharing options...
southsider2k5 Posted January 25, 2021 Share Posted January 25, 2021 9 minutes ago, StrangeSox said: Schools are using school nurses to deliver shots to staff. But the states are just dumping a handful of doses on districts and telling them "hey, figure it out yourself." It all started with the complete and utter failure of the federal government, but just about every state is compeltely failing and abdicating responsibility as well. Why the hell is it up to school superintendents, who have zero public health background, to determine if/when their schools should be open and the vaccine priority and distribution for their schools? Why is Linconl-Way having to develop vaccination plans and submit them to the local health departments? https://patch.com/illinois/newlenox/lincoln-way-districts-submit-vaccination-plans-health-dept Anyway, wonder what you'd see if you overlaying these maps with demographic and poverty heat maps ? The failures of the President reverberate. Instead of treating this like a national emergency or war, he treated it like a wedge issue and sold a partisan viewpoint full of lies and misdirection to the public. That all still ripples \ Link to comment Share on other sites More sharing options...
bmags Posted January 25, 2021 Share Posted January 25, 2021 Just now, StrangeSox said: What about nurses, CNA's, reception, security, and other frontline people exposed to COVID patients in medical settings? Link to comment Share on other sites More sharing options...
Harry Chappas Posted January 25, 2021 Share Posted January 25, 2021 2 hours ago, StrangeSox said: What about nurses, CNA's, reception, security, and other frontline people exposed to COVID patients in medical settings? That is all the health care workers and front line employees live (police, fire, nurses, etc.) Link to comment Share on other sites More sharing options...
bmags Posted January 25, 2021 Share Posted January 25, 2021 very good vaccine. Very very good. 1 Link to comment Share on other sites More sharing options...
StrangeSox Posted January 25, 2021 Share Posted January 25, 2021 (edited) Mostly good Moderna news too. I'm running under the assumption that the Pfizer and Moderna vaccines are basically interchangeable given they're the same platform targeting the same spike protein in the same way, just with slightly different wrappers. https://investors.modernatx.com/news-releases/news-release-details/moderna-covid-19-vaccine-retains-neutralizing-activity-against posted: Moderna COVID-19 Vaccine Retains Neutralizing Activity Against Emerging Variants First Identified in the U.K. and the Republic of South Africa Out of an abundance of caution, Moderna launches clinical program to boost immunity to emerging variants Manuscript posted to preprint server; company to host conference call once manuscript is available CAMBRIDGE, Mass.--(BUSINESS WIRE)--Jan. 25, 2021-- Moderna Inc. (Nasdaq: MRNA), a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, today announced results from in vitro neutralization studies of sera from individuals vaccinated with Moderna COVID-19 Vaccine showing activity against emerging strains of SARS-CoV-2. Vaccination with the Moderna COVID-19 Vaccine produced neutralizing titers against all key emerging variants tested, including B.1.1.7 and B.1.351, first identified in the UK and Republic of South Africa, respectively. The study showed no significant impact on neutralizing titers against the B.1.1.7 variant relative to prior variants. A six-fold reduction in neutralizing titers was observed with the B.1.351 variant relative to prior variants. Despite this reduction, neutralizing titer levels with B.1.351 remain above levels that are expected to be protective. This study was conducted in collaboration with the Vaccine Research Center (VRC) at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). The manuscript has been submitted as a preprint to bioRxiv and will be submitted for peer-reviewed publication. The two-dose regimen of the Moderna COVID-19 Vaccine at the 100 µg dose is expected to be protective against emerging strains detected to date. Nonetheless, Moderna today announced its clinical strategy to proactively address the pandemic as the virus continues to evolve. First, the Company will test an additional booster dose of its COVID-19 Vaccine (mRNA-1273) to study the ability to further increase neutralizing titers against emerging strains beyond the existing primary vaccination series. Second, the Company is advancing an emerging variant booster candidate (mRNA-1273.351) against the B.1.351 variant first identified in the Republic of South Africa. The Company is advancing mRNA-1273.351 into preclinical studies and a Phase 1 study in the U.S. to evaluate the immunological benefit of boosting with strain-specific spike proteins. Moderna expects that its mRNA-based booster vaccine (whether mRNA-1273 or mRNA-1273.351) will be able to further boost neutralizing titers in combination with all of the leading vaccine candidates. “As we seek to defeat the COVID-19 virus, which has created a worldwide pandemic, we believe it is imperative to be proactive as the virus evolves. We are encouraged by these new data, which reinforce our confidence that the Moderna COVID-19 Vaccine should be protective against these newly detected variants,” said Stéphane Bancel, Chief Executive Officer of Moderna. “Out of an abundance of caution and leveraging the flexibility of our mRNA platform, we are advancing an emerging variant booster candidate against the variant first identified in the Republic of South Africa into the clinic to determine if it will be more effective to boost titers against this and potentially future variants.” First detected in September 2020 in the United Kingdom, the SARS-CoV-2 B.1.1.7 variant has seventeen mutations in the viral genome with eight mutations located in the spike (S) protein. The B.1.351 variant, first detected in South Africa, has ten mutations located in the spike (S) protein. Both variants have spread at a rapid rate and are associated with increased transmission and a higher viral burden after infection1,2. The in vitro study assessed the ability of mRNA-1273 to elicit potently neutralizing antibodies against the new SARS-CoV-2 variants, using sera from eight Phase 1 clinical trial participants (aged 18-55 years) who received two 100 µg doses of mRNA-1273, and separately using sera from non-human primates (NHPs) immunized with two doses of 30 µg or 100 µg of mRNA-1273. For the B.1.1.7 variant, neutralizing antibody titers remained high and were generally consistent with neutralizing titers relative to prior variants. No significant impact on neutralization was observed from either the full set of mutations found in the B.1.1.7 variant or from specific key mutations of concern. Although these mutations have been reported to lessen neutralization from convalescent sera and to increase infectivity, sera from the Phase 1 participants and NHPs immunized with mRNA-1273 were able to neutralize the B.1.1.7 variant to the same level as prior variants. For the B.1.351 variant, vaccination with the Moderna COVID-19 Vaccine produces neutralizing antibody titers that remain above the neutralizing titers that were shown to protect NHPs against wildtype viral challenge. While the Company expects these levels of neutralizing antibodies to be protective, pseudovirus neutralizing antibody titers were approximately 6-fold lower relative to prior variants. These lower titers may suggest a potential risk of earlier waning of immunity to the new B.1.351 strains. (..) Edited January 25, 2021 by StrangeSox Link to comment Share on other sites More sharing options...
Texsox Posted January 25, 2021 Share Posted January 25, 2021 6 hours ago, StrangeSox said: Schools are using school nurses to deliver shots to staff. But the states are just dumping a handful of doses on districts and telling them "hey, figure it out yourself." It all started with the complete and utter failure of the federal government, but just about every state is compeltely failing and abdicating responsibility as well. Why the hell is it up to school superintendents, who have zero public health background, to determine if/when their schools should be open and the vaccine priority and distribution for their schools? Why is Linconl-Way having to develop vaccination plans and submit them to the local health departments? https://patch.com/illinois/newlenox/lincoln-way-districts-submit-vaccination-plans-health-dept Anyway, wonder what you'd see if you overlaying these maps with demographic and poverty heat maps ? When I posted we never did this before I was quickly corrected. We did this with the polio vaccine by using schools and churches. Link to comment Share on other sites More sharing options...
StrangeSox Posted January 27, 2021 Share Posted January 27, 2021 Link to comment Share on other sites More sharing options...
bmags Posted January 27, 2021 Share Posted January 27, 2021 53k yesterday in IL. Monday was really low, but take the two day and it’s 40k/day. Fingers crossed for maybe 60k thurs/fri? Link to comment Share on other sites More sharing options...
StrangeSox Posted January 27, 2021 Share Posted January 27, 2021 This guy with Shaw media does a good thread every day on the IDPH's press conference/data releases. Daily state number updates, then vaccine numbers, and then region-by-region info. Link to comment Share on other sites More sharing options...
StrangeSox Posted January 27, 2021 Share Posted January 27, 2021 The top 10 are 1 New Zealand 2 Vietnam 3 Taiwan 4 Thailand 5 Cyprus 6 Rwanda 7 Iceland 8 Australia 9 Latvia 10 Sri Lanka The US is ranked 94th and the UK 66th Link to comment Share on other sites More sharing options...
southsider2k5 Posted January 28, 2021 Share Posted January 28, 2021 Link to comment Share on other sites More sharing options...
greasywheels121 Posted January 28, 2021 Share Posted January 28, 2021 9 hours ago, southsider2k5 said: I think we just figured out how to drive more compliance with masking up and physical distancing. 1 Link to comment Share on other sites More sharing options...
Iwritecode Posted January 28, 2021 Share Posted January 28, 2021 Reminds me of this: 1 Link to comment Share on other sites More sharing options...
StrangeSox Posted January 28, 2021 Share Posted January 28, 2021 Link to comment Share on other sites More sharing options...
bmags Posted January 28, 2021 Share Posted January 28, 2021 On 1/27/2021 at 12:56 PM, bmags said: 53k yesterday in IL. Monday was really low, but take the two day and it’s 40k/day. Fingers crossed for maybe 60k thurs/fri? 50k+ again. 50k a day puts us on track for phase 1c by April 1 like they planned. BTW, if anyone is trying to get appts for their 65+ family in chicago area, I highly recommend just keeping track of the Jewel/Osco (albertsons) website. They let you search across locations for ALL DATES easily. It will probably be full when you look, just keep refreshing and checking back, they do update for cancels and re-schedules. Good luck! 1 Link to comment Share on other sites More sharing options...
StrangeSox Posted January 28, 2021 Share Posted January 28, 2021 2 hours ago, bmags said: 50k+ again. 50k a day puts us on track for phase 1c by April 1 like they planned. BTW, if anyone is trying to get appts for their 65+ family in chicago area, I highly recommend just keeping track of the Jewel/Osco (albertsons) website. They let you search across locations for ALL DATES easily. It will probably be full when you look, just keep refreshing and checking back, they do update for cancels and re-schedules. Good luck! Is Jewel only doing 65+ or anyone in 1b? Link to comment Share on other sites More sharing options...
bmags Posted January 28, 2021 Share Posted January 28, 2021 1 minute ago, StrangeSox said: Is Jewel only doing 65+ or anyone in 1b? anyone in 1b, my sister-in-law got one in (manufacturing) Link to comment Share on other sites More sharing options...
StrangeSox Posted January 28, 2021 Share Posted January 28, 2021 Cool, thanks. Checking out their website, and it's so much more user friendly than Walgreens. You have to check store-by-store, day-by-day, 3-hour-chunk-by-chunk with them. Some great news/bad news on Novavax: 90% efficacy against most strains, but only about 50% effective (with large error bars, so maybe much less, maybe as high as 70% effective) against the SA variant. Link to comment Share on other sites More sharing options...
Balta1701 Posted January 28, 2021 Share Posted January 28, 2021 S***. Link to comment Share on other sites More sharing options...
caulfield12 Posted January 29, 2021 Author Share Posted January 29, 2021 Wow, Novavax has gone from under $5 in early January, 2020...all the way up to $189 and $134 right now. Link to comment Share on other sites More sharing options...
bmags Posted January 29, 2021 Share Posted January 29, 2021 novavax & j&j in two days is great. I don't want to hear any qualifiations about this efficacy. Great great news https://www.statnews.com/2021/01/29/jj-one-dose-covid-vaccine-is-66-effective-a-weapon-but-not-a-knockout-punch/ Link to comment Share on other sites More sharing options...
The Beast Posted January 29, 2021 Share Posted January 29, 2021 (edited) 22 minutes ago, bmags said: novavax & j&j in two days is great. I don't want to hear any qualifiations about this efficacy. Great great news https://www.statnews.com/2021/01/29/jj-one-dose-covid-vaccine-is-66-effective-a-weapon-but-not-a-knockout-punch/ It’s great news that more vaccines are available, now we just have to hope boosters can be given to fight the new variants. Edited January 29, 2021 by The Beast Link to comment Share on other sites More sharing options...
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